Supersaturable formulations
نویسندگان
چکیده
منابع مشابه
A Novel In Silico Screening Protocol For The Selection Of Optimized Precipitation Inhibitor Systems For Supersaturable Formulations
For Supersaturable Formulations D. J. Price, C. Saal, A. Nair, J. Dressman Merck KGaA, Goethe University Purpose Supersaturable formulations represent a viable option for improving bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Given the metastable nature of the supersaturated state, precipitation inhibitors (PIs) are required to sustain API in solution for physiolo...
متن کاملEnhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system.
A new Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)-based supersaturable self-emulsifying drug delivery system (S-SEDDS) was formulated to enhance oral absorption of tacrolimus (FK506) with minimal use of oil, surfactant, and cosurfactant. A high payload supersaturable system (S-SEDDS) was prepared by incorporating Soluplus, as a precipitation inhibitor,...
متن کاملA Polyvinylpyrrolidone-Based Supersaturable Self-Emulsifying Drug Delivery System for Enhanced Dissolution of Cyclosporine A
A novel supersaturable self-emulsifying drug delivery system (S-SEDDS) of cyclosporine A (CyA)—a poorly water-soluble immunosuppressant—was constructed in order to attain an apparent concentration–time profile comparable to that of conventional SEDDS with reduced use of oil, surfactant, and cosolvent. Several hydrophilic polymers, including polyvinylpyrrolidone (PVP), were employed as precipita...
متن کاملEnhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system
A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol...
متن کاملSupersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement
Solid self-emulsifying drug delivery system (SSEDDS), which incorporates liquid SEDDS into a solid dosage form, has been recently introduced to improve the oral bioavail-ability of poorly water-soluble drugs. However, supersaturated drug generated by SSEDDS is thermodynamically unstable and tends to precipitate rapidly prior to absorption, resulting in compromised bioavailability. The aim of th...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2010
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.25.371